Mid-stage trial of long COVID treatment shows promise on fatigue scores
Researchers caution the study is small, but improvements were statistically significant across two key measures.
A Phase 2 trial of an experimental treatment for long COVID reported statistically significant improvements in patient-reported fatigue and cognitive scores after twelve weeks.
Long COVID affects millions and currently has no approved targeted treatments. Even a partial therapy would change clinical guidance.
What we know so far
- The trial enrolled 184 patients across nine sites.
- Improvements were seen on both a validated fatigue scale and a cognitive battery.
- Side effects were mild and similar to placebo.
- Researchers stressed that Phase 3 confirmation is required.
Results from the mid-stage trial were presented at a medical conference on Friday and simultaneously published in a peer-reviewed journal.
The numbers
Patients on the active treatment improved by an average of 11 points on a validated fatigue scale, compared with 4 points for placebo.
Cautions
Researchers emphasized the small sample size and short follow-up. 'These are encouraging signals, not a finish line,' the lead investigator said.
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What comes next
A larger Phase 3 trial is being planned and could begin enrollment later this year. Regulators have not yet weighed in publicly.
This story is developing. Last updated June 14, 2026, 12:15 AM PDT.
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